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Pharmacokinetic Dataset of Acetaminophen

Source: R/data.R
APAP.Rd

The Acetaminophen dataset contains a human experiment of pharmacokinetic data for acetaminophen and it's major metabolites acetaminophen-glucuronide and acetaminophen-sulfate.

Usage

APAP

Format

A data frame containing the following columns:

  • Wt: averaged weight of the study population (kg).

  • Dose: given oral dose of acetaminophen administered (mg/kg).

  • Time: time after drug administration (hr).

  • APAP: concentration of acetaminophen in the sample (mg/L).

  • AG: concentration of acetaminophen-glucuronide in the sample (mg/L).

  • AS: concentration of acetaminophen-sulfate in the sample (mg/L).

  • Study: sourced reference.

References

Zurlinden, T. J., & Reisfeld, B. (2016). Physiologically based modeling of the pharmacokinetics of acetaminophen and its major metabolites in humans using a Bayesian population approach. European journal of drug metabolism and pharmacokinetics, 41(3), 267-280.